Immunocal studies, now in English and properly linked.

The Effect of Supplementation with a Cysteine Donor on Muscular Performance

Oxidative stress contributes to muscular fatigue. Glutathione (GSH) is the major intracellular antioxidant, whose biosynthesis is dependent upon cysteine availability.

Improved Glutathione Status in Young Adult Patients with Cystic Fibrosis Supplemented with Whey Protein

The results show that dietary supplementation with a whey-based product can increase glutathione levels in cystic fibrosis. This nutritional approach may be useful in maintaining optimal levels of GSH and counteract the deleterious effects of oxidative stress in the lung in cystic fibrosis.

Effects of Cysteine Donor Supplementation on Exercise-Induced Bronchoconstriction

Purpose Reactive oxygen/nitrogen species (ROS/ RNS) in resident airway cells may be important in bronchoconstriction following exercise. Glutathione (GSH) is a major lung antioxidant and could influence pathological outcomes in individuals with exercise- induced bronchoconstriction (EIB).This study examined the effects of supplementation with undenatured whey protein (UWP) in subjects exhibiting airway narrowing…

Cysteine-Rich Protein Reverses Weight Loss in Lung Cancer Patients Receiving Chemotherapy or Radiotherapy

Oxidative stress plays a role in the tumorcytotoxic effect of cancer chemotherapy and radiotherapy and also in certain adverse events. In view of these conflicting aspects, a double-blind trial over 6 months has been performed to determine whether a cysteine-rich protein (IMN1207) may have a positive or negative effect on the clinical outcome if compared with casein, a widely used protein supplement low in cysteine.

Effect of Cysteine-Rich Whey Protein (Immunocal®) Supplementation in Combination with Resistance Training on Muscle Strength and Lean Body Mass in Non-Frail Elderly Subjects: A Randomized, Double-Blind Controlled Study

Our findings showed increases in muscle strength in both groups after resistance training, however, significant additional increases were observed in muscle strength with the addition of a cysteine-rich whey protein (Immunocal®) versus casein.

Biochemical and Clinical Effects of Whey Protein Supplementation in Parkinson’s Disease

This study is the first to report that Whey protein supplementation significantly increases plasma reduced glutathione, the reduced to oxidized glutathione ratio, BCAAs and EAAs in patients with PD, together with a concomitant significant reduction of plasma Hcy. However, there were no significant changes in clinical outcomes. Long-term, large randomized clinical studies are needed to explore the benefits of whey…

ABD Bioactives Alleviate Chemotherapy-Induced Myelosuppression

Objective To explore the effect of ABD Bioactives on myelosuppression alleviation in lung cancer patients during chemotherapy. Methods 44 lung cancer patients who received chemotherapywererandomlydividedintoanintervention group and a control group.

Improving Antioxidant Capacity in Children with Autism: A randomized, double-blind controlled study with cysteine- rich whey protein

Previous studies indicate that children with autism spectrum disorder (ASD) have lower levels of glutathione. Nutritional interventions aim to increase glutathione levels suggest a positive effect on ASD behaviors, but findings are mixed or nonsignificant.

Prehabilitation Versus Rehabilitation a Randomized Control Trial in Patients Undergoing Colorectal Resection for Cancer

Meaningful changes in postoperative functional exercise capacity can be achieved with a prehabilitation program.

Prehabilitation with Whey Protein Supplementation on Perioperative Functional Exercise Capacity in Patients Undergoing Colorectal Resection For Cancer: A Pilot Double-Blinded Randomized Placebo-Controlled Trial

Clinically meaningful improvements in functional walking capacity were achieved before surgery with whey protein supplementation. These pilot results are encouraging and justify larger- scale trials to define the specific role of nutrition prehabilitation on functional recovery after surgery.

Multimodal Prehabilitation Improves Functional Capacity Before and After Colorectal Surgery for Cancer: A Five-Year Research Experience

In large secondary analysis, multimodal prehabilitation resulted in greater improvement in walking capacity throughout the whole perioperative period when compared to rehabilitation started after surgery.

Four-Week Prehabilitation Program is Sufficient to Modify Exercise Behaviors and Improve Preoperative Functional Walking Capacity in Patients with Colorectal Cancer

These findings highlight the positive effects of a trimodal prehabilitation program on patients’ physical activity levels and functional walking capacity and demonstrate that modifying exercise behaviors and improving physical function within the 4-week preoperative period are an achievable goal.

Effect Of Exercise and Nutrition Prehabilitation on Functional Capacity in Esophagogastric Cancer Surgery: A Randomized Clinical Trial

Is a key element in the care continuum for patients with esophagogastric cancer. Prehabilitation, a preoperative conditioning intervention aiming to optimize physical status, has not been tested in upper gastrointestinal surgery to date.

Evaluation of Supervised Multimodal Prehabilitation Programme in Cancer Patients Undergoing Colorectal Resection: A Randomized Control Trial

Background Prehabilitation has been previously shown to be more effective in enhancing postoperative functional capacity than rehabilitation alone. The purpose of this study was to determine whether a weekly supervised exercise session could provide further benefit to our current prehabilition program, when comparing to standard post-surgical rehabilitation.

Maximizing Patient Adherence To Prehabilitation: What Do The Patients Say?

Purpose Multimodal prehabilitation programs (exercise, nutrition, and anxiety reduction) have been shown to be successful for enhancing patients’ physical function prior to surgery, although adherence remains a challenge. Given the short pre-operative period, maintaining adherence is critical to maximize program effectiveness.

Effect of Exercise and Nutrition Prehabilitation on Functional Capacity in Esophagogastric Cancer Surgery: A Randomized Clinical Trial

Importance Preserving functional capacity is a key element in the care continuum for patients with esophagogastric cancer. Prehabilitation, a preoperative conditioning intervention aiming to optimize physical status, has not been tested in upper gastrointestinal surgery to date.

Multimodal Prehabilitation to Enhance Functional Capacity Following Radical Cystectomy: A Randomized Controlled Trial

Background In patients with bladder cancer, poor functional status has remarkable deleterious effects on postoperative outcome and prognosis. Conditioning intervention initiated before surgery has the potential to reduce functional decline attributable to surgery.

Trimodal Prehabilitation for Colorectal Surgery Attenuates Post-surgical Losses in Lean Body Mass: A Pooled Analysis of Randomized Controlled Trials

Background & aims Preservation of lean body mass is an important cancer care objective. The capacity for prehabilitation interventions to modulate the lean body mass (LBM) of colorectal cancer patients before and after surgery is unknown.

Depression and Functional Status in Colorectal Cancer Patients Awaiting Surgery: Impact of a Multimodal Prehabilitation Program

Objective Depression and poor functional status (FS) frequently co-occur. Though both predict adverse surgical outcomes, research examining preoperative functional performance (FP; self-reported) and functional capacity (FC; performance-based) measures in depressed cancer patients is lacking.

Medical Supervision for Cancer Patient’s Healthy Lifestyle (MCL) Improves Postoperative Rehabilitation

Objective to explore the effect of medical supervision for cancer (chronic disease) patients’ healthy lifestyle (Mcl) on the postoperative rehabilitation of tumor patients. Methods fifty patients with solid tumor were randomly assigned into the intervention group or the control group.

Effect of Multimodal Prehabilitation vs Postoperative Rehabilitation on 30-Day Postoperative Complications for Frail Patients Undergoing Resection of Colorectal Cancer: A Randomized Clinical Trial

Importance Research supports use of prehabilitation to optimize physical status before and after colorectal cancer resection, but its effect on postoperative complications remains unclear. Frail patients are a target for prehabilitation interventions owing to increased risk for poor postoperative outcomes.

Multimodal Prehabilitation for Lung Cancer Surgery: A Randomized Controlled Trial

In patients undergoing surgical resection for lung cancer within the context of ERP, multimodal prehabilitation initiated four weeks prior to surgery is as effective in recovering FC as multimodal rehabilitation.

Functional capacity of prediabetic patients: effect of multimodal prehabilitation in patients undergoing colorectal cancer resection

Multimodal prehabilitation favored clinical recovery of FC after surgery in CRC patients, especially prediabetic patients.

Older frail prehabilitated patients who cannot attain a 400m 6-min walking distance before colorectal surgery suffer more postoperative complications

Several preoperative characteristics were identified in the <400 m 6MWD group that could be useful in screening and targeting future prehabilitative treatments. Future trials should investigate use of a 400 m standard for the 6MWD as a minimal treatment target for prehabilitation

Malnourished lung cancer patients have poor baseline functional capacity but show greatest improvements with multimodal prehabilitation

Lung cancer patients at high-nutrition- risk awaiting surgery had significantly lower baseline FC compared with low-nutrition-risk patients but experienced significant improvements in preoperative FC upon receiving multi- modal prehabilitation.

Effect of Multimodal Prehabilitation on Reducing Postoperative Complications and Enhancing Functional Capacity Following Colorectal Cancer Surgery - The PREHAB Randomized Clinical Trial

IImportance: Colorectal surgery is associated with substantial morbidity rates and a lowered functional capacity. Optimization of the patient’s condition in the weeks prior to surgery may attenuate these unfavorable sequelae.

Treatment of Chronic Hepatitis Using Whey Protein (Non-Heated)

In an open study, the clinical efficacy of whey protein (Immunocal: cysteine content; 7.6-fold that of casein) isolated from fresh milk and purified without being heated was evaluated based on liver function test, immunological parameters, plasma or lymphocyte GSH concentrations and hepatitis virus markers in 25 patients with chronic hepatitis B or C. Immunocal (12 g as protein) food (mousse) was given twice a day,…

Effect of Whey Protein to Modulate Immune Response in Children with Atopic Asthma

Background: Levels of glutathione (GSH) in antigen- presenting cells promote a T-helper type 2 (Th2) cytokine response in mice. We have previously demonstrated that we can increase intracellular GSH levels in healthy young adults using a wheybased oral supplement (HMS90TM).

Open-Labeled Pilot Study of Cysteine-Rich Whey Protein Isolate Supplementation for Nonalcoholic Steatohepatitis Patients

The results indicate that oral supplementation of cysteine-rich whey protein isolate leads to improvements in liver biochemistries, increased plasma GSH, total antioxidant capacity and reduced hepatic macrovesicular steatosis in NASH patients. The results support the role of oxidative stress in the pathogenesis of this disease.

The effects of glutathione enhancement on sensorineural hearing loss

Previous research has demonstrated the benefits of antioxidant treatment in the prevention of hearing loss in animals. Our study tested the effects of an undenatured whey protein supplement rich in glutathione on human patients with hearing loss.

Cysteine/Cystine-Rich Undenatured Whey Protein Supplement in Patients’ Pressure Ulcers Outcomes: An Open Label Study

By providing the necessary amino acids to rebuild tissues and bioactive cysteine (cystine) to promote synthesis of intracellular GSH and positive nitrogen balance, improvement in PUs healing was achieved.

Whey Proteins as a Food Supplement in HIV-Seropositive Individuals

On the basis of numerous animal experiments, a pilot study was undertaken to evaluate the effect of undenatured, biologically active, dietary whey protein in 3 HIV-seropositive individuals over a period of 3 months. Whey protein concentrate was prepared so that the most thermosensitive proteins, such as serum albumin which contains 6 glutamylcysteine groups, would be in undenatured form.

The Use of a Whey Protein Concentrate in the Treatment of Patients with Metastatic Carcinoma: A Phase I-II Clinical Study

Glutathione (GSH) concentration is high in most tumor cells and this may be an important factor in resistance to chemotherapy. Previous in-vitro and animal experiments have shown a differential response of tumor versus normal cells to various cysteine delivery systems.

Oral Tolerability of Cysteine-Rich Whey Protein Isolate in Autism: A Pilot Study

This study suggests that NWPI can be used as a supplement for this small population of children with autism without high rates of side effects, which means that further studies to determine its safety and efficacy in larger populations might yield the same promising result. Larger studies are planned to determine its efficacy in raising glutathione levels.

Immunocal scientific publication

The positive preliminary outcomes from this pilot study suggest a randomized, double-blind, clinical trial would be worthwhile in evaluating whether this protein isolate would result in statistically significant improvement for patients with psoriasis.

Psoriasis Improvement in Patients Using Glutathione-Enhancing, Nondenatured Whey Protein Isolate: A Pilot Study .54 Treatment of Obstructive Airway Disease with a Cysteine Donor Protein Supplement: A Case Report

Oxidant/antioxidant imbalance can occur in obstructive airways disease, as a result of ongoing inflammation. Glutathione plays a major role in pulmonary antioxidant protection.

Whey Protein Concentrate (WPC) and Glutathione Modulation in Cancer Treatment

The glutathione (GSH) antioxidant system is foremost among the cellular protective mechanisms. Depletion of this small molecule is a common consequence of increased formation of reactive oxygen species during increased cellular activities.

Does the use of cysteine-rich whey protein supplements (Immunocal) improve the health well-being of COVID-19 patients? A qualitative study

Following the daily dosage indications of the consultants, the participants who have consumed Inmunocal® have presented a partial improvement of the symptoms related to COVID-19, however, they feel the need to consume the supplement daily to improve their quality of life.

Use of a Cysteine-Rich whey Protein Isolate as Adjuvant Therapy in Patients with COVID-19 Pneumonia: A Case Series

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 has infected more than 283 million people world- wide and is responsible for nearly 5.5 million deaths. While a significant number of people have recovered from this infection, nearly 40% of the patients who leave the ICU have important complications that compromise their activity of daily living.

Evolutionary Traits in Human Milk Proteins

Human milk has the lowest concentration of protein of any mammalian species. Since the rate of growth of the offspring is negatively related to the protein content of the milk, the time required to double the birth weight is greater in the infant than in any other mammal in which it has been measured.

Whey Proteins in Cancer Prevention

Epidemiological and experimental studies suggest that dietary milk products may exert an inhibitory effect on the development of several types of tumors. Some recent experiments in rodents indicate that the antitumor activity of the dairy products is in the protein fraction and more specifically in the whey protein component of milk.

Place for an Antioxidant Therapy in Human Immunodeficiency Virus (HIV) Infection

Oxidative stress, a known activator of HIV replication in vitro, has a potential role as a cofactor of HIV disease progression. Arguments supporting the role of oxidative stress as a cofactor in HIV activation are summarized in this review.

Nutriceutical Modulation of Glutathione With a Humanized Native Milk Serum Protein Isolate, Immunocal™: Application in AIDS and Cancer

The biological activity of the proteins isolated from cow’s milk in Immunocal™ depends on the preservation of those labile proteins which share with the predominant human milk proteins the same extremely rare glutathione (GSH)-promoting components. Cellular GSH depletion has been implicated in the pathogenesis of a number of degenerative conditions and disease states including Parkinson’s, Alzheimer’s,…

Competition for Glutathione Precursors Between the Immune System and the Skeletal Muscle: Pathogenesis of Chronic Fatigue Syndrome

Thechronicfatiguesyndrome(CFS)istypicallyassociatedor follows a recognized or presumed infection. Abnormalities of both humoral and cellular immunity have been demonstrated in a substantial proportion of patients with CFS.

Therapeutic Functions of Whey Proteins (Turkish)

Recent studies have indicated that whey proteins show some very important therapeutic functions. The antioxidant properties of these protein isolates are essential for nutrition.

The Antioxidant System

The glutathione (GSH) antioxidant system is the principal protective mechanism of the cell and is a crucial factor in the development of the immune response by the immune cells. Experimental data demonstrate that a cysteine-rich whey protein concentrate represents an effective cysteine delivery system for GSH replenishment during the immune response.

Molecular Pathogenesis and Prevention of Prostate Cancer

Studiesinlaboratoryanimalsindicateinhibitionofchemically- induced carcinoma by cystine-rich diets enhancing the cysteine-GSH antioxidant system. The progression of carcinoma of the prostate is also inhibited by these diets, which were later found to raise the level of GSH in the prostate epithelium of man.

Oxidative Stress and Ageing: Is Ageing a Cysteine Deficiency Syndrome?

Reactiveoxygenspecies(ROS)areconstantlyproduced in biological tissues and play a role in various signaling pathways. Abnormally high ROS concentrations cause oxidative stress associated with tissue damage and dysregulation of physiological signals.

Children’s Oncology Group (COG) Nutrition Committee

Children’s Oncology Group (COG) Nutrition Committee was established to further the knowledge of nutrition in children with cancer by education and conduct of clinical trials. A survey of COG institutions revealed lack of conformity in evaluationandcategorizationofnutritionalstatus,andcriteria for nutritional intervention.

Aberrant Insulin Receptor Signaling and Amino Acid Homeostasis as a Major Cause Of Oxidative Stress in Aging?

The mechanisms leading to the increase in free-radical- derived oxidative stress in “normal aging” remained obscure. Here we present our perspective on studies from different fields which reveal a previously unnoticed vicious cycle of oxidative stress.

Bringing Evidence to Complementary and Alternative Medicine in Children With Cancer: Focus on Nutrition-Related Therapies

Children with cancer frequently use complementary and alternative medicine (CAM), especially in conjunction with conventional therapy. Dietary supplements are a commonly used CAM modality, with the prevalence of supplement use ranging from 35% to 50% of children with cancer in surveys completed in the United States.

Immunocal® and Preservation of Glutathione as a Novel Neuroprotective Strategy for Degenerative Disorders of the Nervous System

Oxidative stress and glutathione (GSH) depletion are both recognized as significant contributors to the pathogenesis of many devastating neurodegenerative diseases. In particular, mitochondrial dysfunction leads to the aberrant production and accumulation of reactive oxygen species (ROS) which are capable of oxidizing key cellular proteins, lipids, and DNA, ultimately triggering cell death.

Editorial: Therapeutic Antioxidants for Neurodegenerative Disease

The aberrant production of reactive oxygen species (ROS) within a cell can cause significant oxidative damage to key cellular proteins, lipids, and DNA. Harmful free radical species like ROS can be generated intrinsically via inadvertent “leakage” from the mitochondrial electron transport chain or by oxidant-generating enzymatic systems like NADPH oxidase, xanthine oxidase, glucose oxidase, or nitric oxide…

Progress in Application of Whey Protein Concentrate in the Treatment For Malignancies

As a safe and effective cysteine carrier, whey protein concentrate (WPC) effectively promote the body’s glutathione synthesistherebyelevatingglutathionelevelinserumandtissue and enhancing lymphocyte proliferation and phagocytosis, as well as T helper cells and cytotoxic activity of natural killer T cells, which finally improve the immune system. Second, as quality nitrogen source, WPC significantly improve the…

Therapeutic Potential of Glutathione Augmentation in Cancer Patients Receiving Chemotherapy or Radiotherapy

The majority of cancer patients receiving conventional medical therapy receive chemotherapy, radiotherapy, surgery or palliative support. Nutritional support is increasingly recognized as vital to successful treatment.

Trimodal Prehabilitation for Colorectal Surgery Attenuates Post-Surgical Losses in Lean Body Mass: A Pooled Analysis of Randomized Controlled Trials

Trimodal prehabilitation attenuated the post-surgical LBM loss compared to the loss observed in patients who received the rehabilitation intervention. Patients who receive neither intervention (i.e., standard of care) would belikelytolosemoreLBM.Offeringaprehabilitationprogramto colorectalcancerpatientsawaitingresectionisausefulstrategy to mitigate the impact of the surgical stress response on lean tissue in an ERAS…

Glutathione Precursors Shield the Brain from Trauma

In the United States, approximately onethird of all injury- related deaths are due to traumatic brain injury (TBI). Anyone is at risk for TBI; however, the risk is higher for athletes in contact sports, military personnel, children and the elderly.

Effect of Whey Protein Supplementation on Perioperative Outcomes in Patients with Cancer— A Systematic Review and Meta-Analysis (PROSPERO 2020: CRD42020188666)

Whey protein has several biochemical characteristics which make it an ideal nutritional supplement in cancer. This metaanalysis aims to evaluate the effects of whey on perioperative outcomes in cancer.

Influence of Dietary Lactalbumin Hydrolysate on The Immune System of Mice and Resistance to Salmonellosis

In the present study we investigated the effect of four weeks of treatment with a diet containing lactalbumin hydrolysate (LAH: Nestlé, Vevey, Switzerland) on the immune response of C3H/HeN mice. Our data indicate that it was possible to increase the level of this type of protein in the diet above the minimum requirement (12% LAH) and thus produce augmented humoral immune responsiveness and resistance to…

Influence of Dietary Proteins on the Immune System of Mice

Theeffectofgradedamountsofdietarylactalbumin(L)and casein (C) hydrolysates on the immune responsiveness of C3H/ HeN and DBA/2 strain mice has been investigated by measuring both the specific humoral immune response to sheep red blood cells (SRBC) and the nonspecific splenic cell responsiveness to phytohemagglutinin, concanavalin A and Escherichia coli lipopolysaccharide after stimulation with Mycobacteriurn bovis,…

Influence of Dietary Protein Type on the Immune System of Mice

The effect of graded amounts of dietary lactalbumin (L), casein (C), soy (S), wheat (W) protein and Purina rodent chow (stock diet) on the immune responsiveness of C3H/ HeN mice has been investigated by measuring the specific humoral immune response to sheep red blood cells (SRBC), and horse red blood cells (HRBC) as well as the nonspecific splenic cell responsiveness to phyto-hemagglutinin (PHA) and concanavalin A…

Differential Effect of Dietary Protein Type on the B-Cell and T-Cell Immune Responses in Mice

The effect of graded amounts of dietary lactalbumin (L), casein (C), soy (S), wheat (W) protein and Purina rodent chow (stock diet) on the immune responsiveness of C3H/HeN mice has been investigated by measuring the specific humoral immune response to sheep red blood cells (SRBC), and horse red blood cells (HRBC) as well as the nonspecific splenic cell responsiveness to phyto-hemagglutinin (PHA) and concanavalin A…

Mechanism of Altered B-Cell Response Induced By Changes in Dietary Protein Type in Mice

The effect of 20 g/100 g dietary lactalbumin (L) or casein (C) diets or a nonpurified (NP) diet on the immune responsiveness of C57B1/6J, C3H/HeJ and BALB/cJ mice has been investigated by measuring the response to the T cell-independent antigen, TNP-Ficoll. To investigate the possible influence of dietary protein type on the supply of B lymphocytes, bone marrow lymphocyte production has been examined by a…

Glutathione Augments the Activation of Cytotoxic T Lymphocytes ‘In Vivo’

The activation of cytotoxic T lymphocytes (CTL) in vivo was found to be augmented by glutathione if injected i.p. in the late phase but not in the early phase of the response.

The Immunoenhancing Property of Dietary Whey Protein Concentrate

The plaque-forming cell response to sheep red blood cells was found to be enhanced in mice fed a formula diet containing 20 g lactalbumin /100 g diet in comparison to mice fed equivalent formula diets of similar nutritional efficiency containing 20 g / 100 g diet of either casein, soy, wheat or corn protein, egg albumin, beef or fish protein, Spirulina maxima, or Scenedesmus protein, or Purina mouse chow. This…

Immunoenhancing Property of Dietary Whey Protein in Mice: Role of Glutathione

The spleen cells immune response to sheep red blood cells of C3H/HeJ mice fed a 20 g whey protein/100 g diet is substantially higher than that of mice fed an equivalent casein diet of similar nutritional efficiency. The present study indicates that the observed immunoenhancing effect of the whey protein mixture is dependent on the overall amino acid pattern resulting from the contribution of all its protein…

The Influence of Dietary Whey Protein on Tissue Glutathione and the Diseases of Aging

This study compared the effects of a wheyrich diet (20 g / 100 g diet), with that of Purina mouse chow or casein-rich diet (20 g / 100 g diet), on the liver and heart glutathione content and on the survival of old male C57BL / 6 NIA mice. The study was performed during a limited observation period of 6.3 months.

Changes in Biliary Secretory Immunoglobulins a in Mice Fed Whey Proteins

Background: A whey protein diet has been shown to enhance splenic immune response to sheep red blood cells (SBRC) in mice. This study was designed to investigate the influence of the type of dietary protein on the biliary secretory IgA.

Dietary Milk Proteins Inhibit the Development of Dimethylhydrazine-Induced Malignancy

This study investigated the influence of two formula diets containing 20 g/100 g diet of either whey protein concentrate or casein, or Purina mouse chow on 1,2dimethylhydrazine (DMH)-induced colon carcinoma in A/J mice. Four weeks after the 24th DMH treatment the incidence of tumour and tumour area in the whey protein-fed mice was substantially less in comparison to either the casein or Purina groups.

The Biological Activity of Undenatured Dietary Whey Proteins: Role of Glutathione

This study compared the effects of different sources of wheyproteinconcentrate(20g/100gdiet)andofcaseinon thespleen,liver,andheartglutathionecontentofC3H/HeJ mice, and on the immune response of their spleen cells to sheepredbloodcells.Bodyweightcurvesweresimilarinall dietary groups. Our data indicate that the humoral immune response is highest in mice fed a dietary whey protein concentrate exhibiting the highest…

Milk Whey Protein Decreases Oxygen Free Radical Production in a Murine Model of Chronic Iron-Overload Cardiomyopathy

Chronic iron overload is a major cause of organ failure worldwide, but its pathogenesis remains to be elucidated. To examine in an experimental murine model of iron-overload cardiomyopathy the relation between milk whey protein and, first, the production of reactive oxygen free radical species and, second, antioxidant reserve status.

Dietary protein, immune function and colon carcinogenesis in the mouse

Immune stimulation and colon cancer development were studied in A/J mice injected with azoxymethane (AOM) which were maintained on undenatured whey protein concentrate (WPC), Immunocal (IM), soy protein isolate (SPI) and a commercial casein (CC) as the only source of dietary protein for 32 weeks. No difference in growth rate and body weight was found for the different treatments.

Effects of Whey Protein Concentrate (WPC) on the Distributions of Lymphocyte Subpopulations in Rats with Excessive Alcohol Intake

To investigate the effects of whey protein concentrate (WPC) on antioxidant statuses and the lymphocyte subpopulations in the rats with alcohol intake, the antioxidant statuses in the peripheral blood (PB) and the lymphocyte subpopulations in the PB, spleen, and bone marrow (BM) of the rats fed with WPC (0.334 g/ kg) and alcohol (6 g/kg) for 3 months were analyzed. Results showed that the effects of WPC on the…

A whey-based glutathione-enhancing diet decreases allergen-induced airway contraction in a guinea-pig model of asthma

Since an allergen-induced early asthmatic reaction is likely to be accompanied by oxidative stress and since levels of the endogenous anti- oxidant glutathione can be enhanced by a whey-based diet (undenatured whey protein concentrate, UWPC), it was investigated whether UWPC could alleviate allergen-induced lung contractions. Guinea pigs were fed water or UWPC twice a day starting at day 23 up to day 20.

A Cysteine-Rich Whey Supplement (Immunocal®) Delays Disease Onset and Prevents Spinal Cord Glutathione Depletion in the Hsod1 (G93a) Mouse Model of Amyotrophic Lateral Sclerosis

Background: Depletion of the endogenous antioxidant, glutathione (GSH), underlies progression of the devastating neurodegenerative disease, amyotrophic lateral sclerosis (ALS). Thus, strategies aimed at elevating GSH may yield new therapeutics for ALS.

Cysteine-Rich Whey Protein Isolate (Immunocal®) Ameliorates Deficits in The GFAP.HMOX1 Mouse Model of Schizophrenia

Background: Depletion of the endogenous antioxidant, glutathione (GSH), underlies progression of the devastating neurodegenerative disease, amyotrophic lateral sclerosis (ALS). Thus, strategies aimed at elevating GSH may yield new therapeutics for ALS.

Whey Protein Concentrate and Dexamethasone Protected Rat Cerebellum from Gamma-radiation Injury

The possible radioprotective effect of Immunocal® (whey protein]) supplement and dexamethasone on gamma- irradiated cerebellar tissue of Wistar rat was investigated in this study. Forty male albino rats were acclimatized and randomized into four groups of 10 animals each.

Selective effects of whey protein concentrate on glutathione levels and apoptosis in rats with mammary tumors

Glutathione (GSH) plays an important role in antioxidant defense and regulation of apoptosis. GSH deficiency is related to many diseases, including cancer, and increased GSHlevelsincancercellsareassociatedwithchemotherapy resistance because of resistance to apoptosis.

The Nutritional Activity of Active Whey Protein in Pancreatic Tumor-Bearing Nude Mice

Active whey protein can prevent the weight loss in transplanted pancreatic mice, prolong the survival time, and this may be associated with preventing and curing cancer cachexia. Key words: whey protein, cancer, nutritional therapy, glutathione.

The Cysteine-Rich Whey Protein Supplement, Immunocal® , Preserves Brain Glutathione and Improves Cognitive, Motor, and Histopathological Indices of Traumatic Brain Injuury in a Mouse Model of Controlled Cortical Impact

Background: Traumatic brain injury (TBI) is a major public health problem estimated to affect nearly 1.7 million people in the United States annually. Due to the often debilitating effects of TBI, novel preventative agents are highly desirable for at risk populations.

Effect study of active whey protein on the nutritional therapy of pancreatic cancer xenografts in nude mice

Objective Active whey protein preserved the active ingredients in cow milk processed with patented low temperature extraction technology. Protein contents up to 90%.

Effects of Active Whey Protein on Nutritional and Immune Status of Mice Bearing Triple-Negative Breast Cancer with Chemotherapy

PurposeToinvestigatetheeffectofactivewheyprotein(ABD) on nutritional and immune status of mice bearing triple- negative breast cancer(TNBC) undergoing chemotherapy. Methods The triple-negative breast cancer 4T1 cells were inoculated in BALB/c mice.

Glutathione Augments the Activation of Cytotoxic T Lymphocytes ‘in Vivo’

The activation of cytotoxic T lymphocytes (CTL) in vivo was found to be augmented by glutathione if injected i.p. in the late phase but not in the early phase of the response.

Dietary Whey Protein Inhibits the Development of Dimethylhydrazine-Induced Malignancy

This study investigates the influence of two formula diets containing 20 g/100 g diet of either whey protein concentrate or casein or Purina mouse chow, on the humoral immune responsiveness and dimethylhydrazine induced colon carcinogenesis in A/J mice. After 20 weeks of dimethylhydrazine treatment, the number of plaque forming cells per spleen, following intravenous inoculation with 5 x 106 sheep red blood cells,…

Cysteine-Rich Whey Protein Isolate (CR-WPI) Ameliorates Erectile Dysfunction by Diminishing Oxidative Stress via DDAH/ADMA/NOS Pathway

Objective Nitric oxide synthase- (NOS-) dependent endothelial dysfunction induced by oxidative stress (OS) is assumed to play a pivotal role in the pathogenesis and progression of diabetes mellitus-related erectile dysfunction (DMED). Cysteine-rich whey protein isolate (CR-WPI) is a OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, Mar 21;2022:8151917 widely used protein supplement and has been confirmed to reduce reactive…

Immunocal scientific publication

Anti-HIV and Anti-Apoptotic Activity of the Whey Protein Concentrate: Immunocal

Immunocal (WPC) possesses antiviral and anti-apoptotic activities which may be related to its glutathione promoting activity. A clinical trial is currently going on with children with AIDS and wasting syndrome.

In Vitro Selective Modulation of Cellular GSH by a Humanized Native Milk Protein Isolate in Normal Cells and Rat Mammary Carcinoma Model

We report the in vitro selective inhibitory activity of a humanized whey protein concentrate ImmunocalTM on growth of mammary carcinoma cells and Jurkat T cells in comparison to normal peripheral blood mononuclear cells. We related this inhibitory activity to a selective depletion of intracellular glutathione synthesis.

Enhancing Effect of Patented Whey Protein Isolate (Immunocal® ) on the Cytotoxicity of Anti-Cancer Drug

To determine the enhancing effect of a whey protein isolate on the cytotoxicity of a potential anti-cancer drug, baicalein, human hepatoma cell line HepG2 was assigned to grow in different media for four days, followed by the investigation of cell growth and apoptosis. Excluding the control group with normal medium, other three treatment media included whey protein isolate (marketed as Immunocal®) medium, baicalein…

Whey Protein Concentrate Promotes the Production of Glutathione (GSH) By Gsh Reductase in The PC12 Cell Line after Acute Ethanol Exposure

Excessive ethanol consumption may increase the production of reactive oxygen species (ROS), which results in the damage of tissues, especially the neurons and glial cells in the central nervous system (CNS). The purpose of this study is to evaluate the effects of whey protein concentrate (WPC) on the glutathione (GSH) status after acute ethanol exposure in the pheochromocytoma (PC12) cell line.

Effects of Alcohol-Induced Human Peripheral Blood Mononuclear Cell (PBMC) Pretreated Whey Protein Concentrate (WPC) on Oxidative Damage

Excessive alcohol consumption can induce apoptosis in a variety of tissues and influence the antioxidant status in peripheral blood mononuclear cells (PBMC). This paper investigates the effects of whey protein concentrate (WPC) pretreated in PBMC on the apoptosis and antioxidant status after the treatment of alcohol.

Whey Protein Concentrate Renders MDA-MB-231 Cells Sensitive to Rapamycin by Altering Cellular Redox State and Activating GSK3ẞ/ mTOR Signaling

Whey protein concentrate (WPC) is an amino acid-rich supplement that has been shown to increase cellular antioxidantcapacity.Mammaliantargetofrapamycin(mTOR) is a crucial regulator of signaling in mammalian cells, and servesasatherapeutictargetfortriple-negativebreastcancer (TNBC). This study was designed to investigate the effect of combining WPC with rapamycin on MDA-MB-231 human breast cancer cells.